|
1 / 1
|
DeCS
|
|
 |
|
Descriptor English:
|
|
NFATC Transcription Factors
|
|
Descriptor Spanish:
|
|
Factores de Transcripción NFATC
|
|
Descriptor Portuguese:
|
|
Fatores de Transcrição NFATC
|
|
Synonyms English:
|
|
NFAT Transcription Factor 1
NFAT Transcription Factor 2
NFAT Transcription Factor 3
NFAT Transcription Factor 4
NFAT Transcription Factor 5
Nuclear Factors of Activated T-Cells
|
|
Tree Number:
|
|
D12.776.930.608
|
|
Definition English:
|
|
A family of transcription factors characterized by the presence of highly conserved calcineurin- and DNA-binding domains. NFAT proteins are activated in the CYTOPLASM by the calcium-dependent phosphatase CALCINEURIN. They transduce calcium signals to the nucleus where they can interact with TRANSCRIPTION FACTOR AP-1 or NF-KAPPA B and initiate GENETIC TRANSCRIPTION of GENES involved in CELL DIFFERENTIATION and development. NFAT proteins stimulate T-CELL activation through the induction of IMMEDIATE-EARLY GENES such as INTERLEUKIN-2. |
|
History Note English:
|
|
2006(1993)
|
|
Allowable Qualifiers English:
|
|
|
|
Record Number:
|
|
51192
|
|
Unique Identifier:
|
|
D050778
|
Occurrence in VHL:
|
|
|
Similar:
|
|
DeCS CID-10 SciELO LILACS LIS
|